Glucokinase (GCK) Rabbit Polyclonal Antibody (CAB15059)
- SKU:
- CAB15059
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | Glucokinase (GCK) Rabbit Polyclonal Antibody |
SKU: | CAB15059 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-465 of human Glucokinase (Glucokinase (GCK)) (NP_000153.1). |
Sequence: | RMCV NTEW GAFG DSGE LDEF LLEY DRLV DESS ANPG QQLY EKLI GGKY MGEL VRLV LLRL VDEN LLFH GEAS EQLR TRGA FETR FVSQ VESD TGDR KQIY NILS TLGL RPST TDCD IVRR ACES VSTR AAHM CSAG LAGV INRM RESR SEDV MRIT VGVD GSVY KLHP SFKE RFHA SVRR LTPS CEIT FIES EEGS GRGA ALVS AVAC KKAC MLGQ |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; PNDM1; FGQTL3; Glucokinase (GCK) |
Positive Sample: | Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia.
Purification Method: | Affinity purification |
Gene ID: | 2645 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |