The GCHFR Polyclonal Antibody (PACO09431) is a valuable tool for researchers studying GCHFR, an enzyme involved in the synthesis of tetrahydrobiopterin (BH4), a critical cofactor in neurotransmitter synthesis. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards GCHFR in human samples, making it an excellent choice for Western blot applications.GCHFR, also known as GTP cyclohydrolase I feedback regulator, plays a key role in the regulation of BH4 biosynthesis, which is essential for the production of neurotransmitters like serotonin, dopamine, and norepinephrine.
Dysregulation of BH4 synthesis has been implicated in various neurological disorders, making GCHFR a promising target for therapeutic interventions.By using the GCHFR Polyclonal Antibody, researchers can uncover the molecular mechanisms underlying BH4 synthesis and its role in neurological health and disease. This antibody enables precise detection and analysis of GCHFR expression in different cell types, providing valuable insights into the pathogenesis of neurological disorders and potential therapeutic strategies.
GTP cyclohydrolase I feedback regulator;GCHFR;GFRP;HsT16933;MGC138467;MGC138469;P35 ;
UniProt Protein Function:
GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity
UniProt Protein Details:
NCBI Summary:
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
