The GCHFR Polyclonal Antibody (PACO03840) is a valuable tool for researchers studying the GCHFR protein, which plays a crucial role in the regulation of tetrahydrobiopterin (BH4) biosynthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is well-suited for use in Western blot applications. By binding specifically to the GCHFR protein, this antibody allows for easy detection and analysis in a variety of cell types.GCHFR, also known as GTP cyclohydrolase I feedback regulatory protein, is essential for maintaining optimal levels of BH4, a cofactor involved in the synthesis of neurotransmitters like serotonin, dopamine, and norepinephrine.
Dysregulation of BH4 biosynthesis has been linked to various neurological disorders, making GCHFR a target of interest for research in neuroscience and pharmacology. By understanding the function of GCHFR, researchers may uncover new insights into the pathophysiology of these conditions and potentially identify novel therapeutic strategies.
Antibody Name:
GCHFR Antibody
Antibody SKU:
PACO03840
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Rat
Immunogen:
synthesized peptide derived from the Internal region of human GFRP.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity
UniProt Protein Details:
NCBI Summary:
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
