GCDH Rabbit Polyclonal Antibody (CAB9057)
- SKU:
- CAB9057
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | GCDH Rabbit Polyclonal Antibody |
SKU: | CAB9057 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 149-438 of human GCDH (NP_000150.1). |
Sequence: | MHPI YAYG SEEQ RQKY LPQL AKGE LLGC FGLT EPNS GSDP SSME TRAH YNSS NKSY TLNG TKTW ITNS PMAD LFVV WARC EDGC IRGF LLEK GMRG LSAP RIQG KFSL RASA TGMI IMDG VEVP EENV LPGA SSLG GPFG CLNN ARYG IAWG VLGA SEFC LHTA RQYA LDRM QFGV PLAR NQLI QKKL ADML TEIT LGLH ACLQ LGRL KDQD KAAP EMVS LLKR NNCG KALD IARQ ARDM LGGN GISD EYHV IRHA MNLE AVNT YEGT HDIH ALIL GRAI TGIQ AFTA SK |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | GCD; ACAD5; GCDH |
Positive Sample: | HL-60,LO2,MCF7,BT-474,Mouse liver,Rat liver,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 48kDa |
Observed MW: | 48kDa |
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12.
Purification Method: | Affinity purification |
Gene ID: | 2639 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |