The Granulophilin/Grancalcin Polyclonal Antibody (CAB7086) is a valuable tool for researchers studying the protein Grancalcin, which plays a key role in granulocyte activation and function. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to Grancalcin, researchers can effectively detect and analyze this protein in a variety of cell types, making it an ideal choice for studies in immunology, inflammation, and cell biology.Grancalcin is an essential regulator of granulocyte function, involved in processes such as degranulation and cytokine production.
Dysregulation of Grancalcin has been implicated in various diseases, including inflammatory disorders and cancer. Therefore, understanding the role of Grancalcin at the molecular level is crucial for developing targeted therapies and diagnostic tools for these conditions.With its specificity and sensitivity, the Granulophilin/Grancalcin Polyclonal Antibody (CAB7086) provides researchers with a reliable tool for investigating the function and regulation of Grancalcin in health and disease. Its utility extends to a wide range of research areas, making it a valuable addition to any lab working in the fields of immunology and oncology.
Product Name:
GCA Rabbit Polyclonal Antibody
SKU:
CAB7086
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1).
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
25801
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GCA antibody (CAB7086) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
