GBP4 Antibody (PACO57396)
- SKU:
- PACO57396
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GBP4 Antibody (PACO57396)
The GBP4 Polyclonal Antibody (PAC057396) is a valuable tool for researchers studying the GBP4 protein, which is involved in immune regulation and cell signaling pathways. This antibody is raised in rabbits and has high reactivity with human samples, making it ideal for use in Western blot applications. By specifically binding to GBP4, researchers can accurately detect and analyze this protein in a variety of cell types.GBP4, also known as guanylate-binding protein 4, plays a crucial role in immune response modulation and has been implicated in various diseases, including cancer and inflammatory conditions.
Understanding the function and expression of GBP4 is essential for advancing research in immunology and developing targeted therapies for these diseases. The GBP4 Polyclonal Antibody is a powerful tool for investigating the role of GBP4 in immune regulation and its potential as a therapeutic target.
| Antibody Name: | GBP4 Antibody (PACO57396) |
| Antibody SKU: | PACO57396 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Guanylate-binding protein 4 protein (494-603AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: 293T whole cell lysate. All lanes: GBP4 antibody at 2.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 74 kDa. Observed band size: 74 kDa. |
 | IHC image of PACO57396 diluted at 1:800 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO57396 diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). |
| Synonyms: | Guanylate-binding protein 4 (EC 3.6.5) (GTP-binding protein 4) (GBP-4) (Guanine nucleotide-binding protein 4), GBP4 |
| UniProt Protein Function: | GBP4: Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. Belongs to the GBP family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Hydrolase; Vesicle Chromosomal Location of Human Ortholog: 1p22.2 Cellular Component: Golgi membrane; nucleus; perinuclear region of cytoplasm Molecular Function:GTP binding; GTPase activity Biological Process: metabolic process |
| NCBI Summary: | Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008] |
| UniProt Code: | Q96PP9 |
| NCBI GenInfo Identifier: | 116242487 |
| NCBI Gene ID: | 115361 |
| NCBI Accession: | Q96PP9.2 |
| UniProt Secondary Accession: | Q96PP9,Q05D63, Q6NSL0, Q86T99, B2R630, |
| UniProt Related Accession: | Q96PP9 |
| Molecular Weight: | 73,165 Da |
| NCBI Full Name: | Guanylate-binding protein 4 |
| NCBI Synonym Full Names: | guanylate binding protein 4 |
| NCBI Official Symbol: | GBP4Â Â |
| NCBI Official Synonym Symbols: | Mpa2Â Â |
| NCBI Protein Information: | guanylate-binding protein 4 |
| UniProt Protein Name: | Guanylate-binding protein 4 |
| UniProt Synonym Protein Names: | GTP-binding protein 4; GBP-4; Guanine nucleotide-binding protein 4 |
| Protein Family: | Guanylate-binding protein |
| UniProt Gene Name: | GBP4Â Â |
| UniProt Entry Name: | GBP4_HUMAN |
| Antibodies | ELISA Kits |
| GBP4 Antibody (PACO02432) | Human Guanylate-binding protein 4 (GBP4) ELISA Kit |
| GBP4 Antibody (PACO09427) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
GBP4 Antibody (PACO09427)
GBP4 Antibody (PACO02432)
Human Guanylate-binding protein 4 (GBP4) ELISA Kit (HUEB1937)
Mouse Guanylate-binding protein 4 (Gbp4) ELISA Kit (MOEB1680)
