The GBA Rabbit Monoclonal Antibody (CAB19057) is a high-quality tool for research involving GBA, a critical enzyme involved in lipid metabolism. This antibody, developed through rabbit immunization, exhibits high specificity and sensitivity for detecting GBA protein in various samples, particularly in human tissues. Validated for use in applications such as Western blot, immunofluorescence, and immunohistochemistry, this antibody allows for precise and reliable detection of GBA expression in cell lines and tissues.GBA, also known as glucocerebrosidase, is essential for the breakdown of glucosylceramide, a lipid molecule implicated in several lysosomal storage disorders, including Gaucher disease.
Dysregulation of GBA activity has been linked to various neurodegenerative diseases, making it a focal point in research related to Parkinson's disease and related conditions. The GBA Rabbit Monoclonal Antibody provides researchers with a valuable tool for investigating the role of GBA in disease pathogenesis and potential therapeutic strategies.
This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2629
Clone Number:
ARC0500
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Glucosylceramidase beta (GBA) Rabbit mAb (CAB19057) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
