The GATM Polyclonal Antibody (CAB6598) is a valuable tool for researchers studying the GATM protein, which plays a key role in creatine biosynthesis and energy metabolism. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.GATM, also known as guanidinoacetate N-methyltransferase, is essential for the production of creatine, a crucial molecule for energy storage and transfer in cells, particularly in tissues with high energy demands like muscle and brain. Dysregulation of GATM has been linked to a variety of conditions including neurological disorders, muscle wasting diseases, and metabolic disorders.
By targeting the GATM protein, researchers can gain insights into the regulation of creatine synthesis and its impact on cellular energy metabolism. This antibody enables the detection and analysis of GATM in various cell types, making it an ideal tool for studies in metabolism, neurobiology, and muscle physiology. Understanding the function of GATM could lead to new therapeutic strategies for treating diseases related to creatine deficiency and energy metabolism dysfunction.
Product Name:
GATM Rabbit Polyclonal Antibody
SKU:
CAB6598
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 38-423 of human GATM (NP_001473.1?).
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by cognitive disability, language impairment, and behavioral disorders.
Purification Method:
Affinity purification
Gene ID:
2628
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GATM Rabbit pAb (CAB6598) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
