GATA5 Antibody (PACO47178)
- SKU:
- PACO47178
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | GATA5 Antibody (PACO47178) |
| Antibody SKU: | PACO47178 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Transcription factor GATA-5 protein (336-397AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO47178 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO47178 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. |
| Synonyms: | Transcription factor GATA-5 (GATA-binding factor 5), GATA5 |
| UniProt Protein Function: | GATA5: Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity; zinc ion binding Biological Process: anatomical structure formation; blood coagulation; cell development; cell fate commitment; heart development; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BWX5 |
| NCBI GenInfo Identifier: | 20138325 |
| NCBI Gene ID: | 140628 |
| NCBI Accession: | Q9BWX5.1 |
| UniProt Secondary Accession: | Q9BWX5,Q17RE2, Q86VU4, D9ZGF7, |
| UniProt Related Accession: | Q9BWX5 |
| Molecular Weight: | 41,299 Da |
| NCBI Full Name: | Transcription factor GATA-5 |
| NCBI Synonym Full Names: | GATA binding protein 5 |
| NCBI Official Symbol: | GATA5Â Â |
| NCBI Official Synonym Symbols: | GATAS; bB379O24.1Â Â |
| NCBI Protein Information: | transcription factor GATA-5 |
| UniProt Protein Name: | Transcription factor GATA-5 |
| UniProt Synonym Protein Names: | GATA-binding factor 5 |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA5Â Â |
| UniProt Entry Name: | GATA5_HUMAN |
| Antibodies | ELISA Kits |
| GATA5 Antibody (PACO03508) | Human GATA5 ELISA Kit |
| Human GATA5 (GATA Binding Protein 5) ELISA Kit (HUES02011) | |
| Human Transcription factor GATA-5 (GATA5) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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