The GATA4 Rabbit Monoclonal Antibody (CAB4306) is a powerful tool for researchers studying GATA4, a transcription factor involved in the regulation of gene expression. This antibody, produced in rabbit, exhibits high specificity and sensitivity towards GATA4 in human samples, making it ideal for Western blotting and immunohistochemistry studies.GATA4 plays a crucial role in various biological processes, including cardiac development, endoderm differentiation, and regulation of cell growth. Dysregulation of GATA4 has been implicated in heart defects and certain cancers, highlighting its importance in both development and disease.
By targeting GATA4 with this antibody, researchers can gain valuable insights into its function and potential therapeutic applications in cardiovascular disease and cancer research.Overall, the GATA4 Rabbit Monoclonal Antibody (CAB4306) offers researchers a reliable tool for investigating the role of GATA4 in various cellular processes and disease states, ultimately contributing to advancements in biomedical research and drug development.
Product Name:
GATA4 Rabbit Monoclonal Antibody
SKU:
CAB4306
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 343-442 of human GATA4 (NP_002043.2).
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2626
Clone Number:
ARC51718
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse testis, using GATA4 Rabbit mAb (CAB4306) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
