The GATA4 Polyclonal Antibody (CAB13756) is a valuable tool for researchers studying GATA4, a transcription factor that plays a key role in heart development and function. This antibody, raised in rabbits, exhibits high specificity and sensitivity for detecting GATA4 in human samples, making it ideal for use in Western blot applications. By targeting the GATA4 protein, this antibody allows for accurate and reliable analysis of its expression levels in various cell types, offering insight into its role in cardiac biology and disease.GATA4 is essential for the proper formation and functioning of the heart, making it a critical target for investigation in cardiovascular research.
Dysregulation of GATA4 is associated with congenital heart defects, cardiac hypertrophy, and other cardiovascular disorders, highlighting its importance in cardiac pathophysiology. By studying GATA4 expression and activity using this antibody, researchers can gain a better understanding of its impact on heart development and disease progression, potentially leading to the development of novel therapeutic strategies for heart-related conditions.
Product Name:
GATA4 Rabbit Polyclonal Antibody
SKU:
CAB13756
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 341-440 of human GATA4 (NP_002043.2).
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2626
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GATA4 Rabbit pAb (CAB13756) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
