The GATA2 Polyclonal Antibody (CAB0677) is a research tool designed for the study of GATA2, a transcription factor essential for the development and function of hematopoietic stem cells. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it well-suited for use in Western blot applications.GATA2 is known for its crucial role in the regulation of hematopoiesis, playing a critical part in the maintenance of blood cell production and differentiation. Dysregulation of GATA2 has been implicated in various hematologic disorders, including leukemia and myelodysplastic syndromes.
Research into the functions and mechanisms of GATA2 is essential for advancing our understanding of these diseases and potentially identifying new therapeutic targets.By using the GATA2 Polyclonal Antibody, researchers can accurately detect and study GATA2 protein levels in different cell types and experimental conditions, providing valuable insights into its biological functions. This antibody is a valuable tool for investigators working in the fields of hematology, oncology, and stem cell biology who are interested in unraveling the complexities of GATA2-mediated pathways and their implications in disease.
Product Name:
GATA2 Rabbit Polyclonal Antibody
SKU:
CAB0677
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GATA2 (NP_116027.2).
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2624
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using GATA2 Rabbit pAb (CAB0677) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
