Pepsinogen II Rabbit Polyclonal Antibody (CAB2788)
- SKU:
- CAB2788
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | Pepsinogen II Rabbit Polyclonal Antibody |
SKU: | CAB2788 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 73-172 of human Pepsinogen II (PG II) (NP_001159896.1). |
Sequence: | YFGE ISIG TPPQ NFLV LFDT GSSN LWVP SVYC QSQA CTSH SRFN PSES STYS TNGQ TFSL QYGS GSLT GFFG YDTL TVQS IQVP NQEF GLSE NEPG TNFV |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:200 |
Synonyms: | PEPC; PGII; Pepsinogen II (PG II) |
Positive Sample: | Mouse liver,Mouse heart,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 42kDa |
Observed MW: | 45-50kDa |
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Purification Method: | Affinity purification |
Gene ID: | 5225 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |