Pepsinogen II Rabbit Polyclonal Antibody (CAB2788)
The Gastricsin Polyclonal Antibody (CAB2788) is a vital tool for researchers studying Gastricsin, a digestive enzyme involved in the breakdown of proteins in the stomach. This antibody, produced using rabbits, offers high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the Gastricsin protein, researchers can accurately detect and analyze its presence in various cell types, making it an essential component for investigations in the fields of gastrointestinal physiology and pathology.Gastricsin, also known as pepsinogen C, plays a crucial role in the digestive process by breaking down proteins into smaller peptides.
Its function is essential for proper nutrient absorption and overall digestive health. Research on Gastricsin is valuable for understanding conditions such as peptic ulcers, gastritis, and other gastrointestinal disorders where enzyme activity may be dysregulated. By studying the mechanisms and regulation of Gastricsin, researchers can uncover new insights into the pathophysiology of these diseases and potentially identify novel therapeutic targets.
Product Name:
Pepsinogen II Rabbit Polyclonal Antibody
SKU:
CAB2788
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 73-172 of human Pepsinogen II (PG II) (NP_001159896.1).
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
5225
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Pepsinogen II (PG II) antibody (CAB2788) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
