The GAS8 Polyclonal Antibody (PACO19696) is a valuable tool for researchers studying GAS8, a protein involved in various cellular functions including microtubule stability and cell cycle regulation. This antibody, produced in rabbits, has high reactivity with human samples and is optimized for use in Western blot applications. By specifically binding to the GAS8 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cell biology and cancer research.GAS8 is known for its role in regulating microtubule dynamics, cell division, and cell migration, making it an intriguing target for research on cellular processes and cancer development.
Understanding the functions of GAS8 can provide insights into its potential as a therapeutic target for diseases where dysregulation of the cell cycle and microtubule dynamics play a role. Researchers studying GAS8 with this antibody can gain valuable information that may contribute to advancements in cancer therapy and cell biology research.
Antibody Name:
GAS8 Antibody (PACO19696)
Antibody SKU:
PACO19696
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human GAS8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19696(GAS8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19696(GAS8 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms:
growth arrest-specific 8
UniProt Protein Function:
GAS8: Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility. Belongs to the GAS8 family.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 16q24.3Cellular Component: Golgi apparatus; microtubuleMolecular Function: Rab GTPase bindingBiological Process: negative regulation of cell proliferation; sperm motility
UniProt Protein Details:
NCBI Summary:
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
