The GAS8 Polyclonal Antibody (PACO09417) is a valuable tool for researchers studying GAS8, a protein involved in regulating cell growth and division. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in Western blot applications with human samples. By binding to the GAS8 protein, this antibody allows for the detection and analysis of GAS8 expression in various cell types, making it an ideal choice for studies in cell biology and cancer research.GAS8 is known for its role in microtubule organization and cell cycle progression, making it a key player in maintaining cellular function and integrity.
Dysregulation of GAS8 has been implicated in various disease states, including cancer and developmental disorders, highlighting the importance of further research into its molecular mechanisms. By using the GAS8 Polyclonal Antibody, researchers can gain valuable insights into the function of GAS8 and potentially uncover new therapeutic targets for disease intervention.
GAS8: Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility. Belongs to the GAS8 family.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 16q24.3Cellular Component: Golgi apparatus; microtubuleMolecular Function: Rab GTPase bindingBiological Process: negative regulation of cell proliferation; sperm motility
UniProt Protein Details:
NCBI Summary:
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
