The GAS8 Polyclonal Antibody (PACO03824) is a valuable tool for researchers studying the GAS8 protein, an important component involved in cytoskeleton organization and cell morphology. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to GAS8, researchers can accurately detect and analyze this protein in various cell types, making it an ideal choice for studies in cell biology and cancer research.
GAS8 is a crucial regulator of microtubule dynamics and has been implicated in cell division, migration, and signaling pathways. Its role in maintaining cellular integrity and function makes it a target of interest in understanding diseases like cancer and neurodevelopmental disorders. By investigating the function of GAS8, researchers can gain insights into how disruptions in cytoskeletal organization contribute to disease progression and potentially identify new therapeutic targets for intervention.
Antibody Name:
GAS8 Antibody
Antibody SKU:
PACO03824
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Gas8.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
GAS8; GAS11; Growth arrest-specific protein 8; GAS-8; Growth arrest-specific protein 11; GAS-11
UniProt Protein Function:
GAS8: Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility. Belongs to the GAS8 family.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 16q24.3Cellular Component: Golgi apparatus; microtubuleMolecular Function: Rab GTPase bindingBiological Process: negative regulation of cell proliferation; sperm motility
UniProt Protein Details:
NCBI Summary:
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
