The GAREM1 Polyclonal Antibody (PAC040586) is a valuable tool for researchers studying GAREM1, a protein involved in various cellular processes such as signal transduction and protein binding. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the GAREM1 protein, it allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell signaling pathways and cancer research.GAREM1, also known as Grb2-related adaptor protein with a PH domain, is a key player in regulating intracellular signaling cascades and mediating interactions between proteins.
Its role in cell proliferation, migration, and differentiation highlights its importance in various physiological and pathological processes. Research on GAREM1 can provide insights into diseases such as cancer, diabetes, and neurodegenerative disorders, paving the way for the development of targeted therapies and diagnostic tools. By utilizing the GAREM1 Polyclonal Antibody, researchers can delve deeper into the functions and mechanisms of GAREM1, contributing to the advancement of knowledge in cell biology and potential therapeutics.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO40586 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO40586 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.
Synonyms:
GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1), GAREM1, C18orf11 FAM59A GAREM
UniProt Protein Function:
GAREM: a protein of unknown function. Contains a predicted ATPase (AAA+ superfamily).Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 18q12.1Cellular Component: plasma membraneMolecular Function: protein bindingBiological Process: epidermal growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell proliferation
UniProt Protein Details:
NCBI Summary:
This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GRB2-associated and regulator of MAPK protein; protein FAM59A; GRB2-associated and regulator of MAPK1; Grb2-associated and regulator of Erk/MAPK; family with sequence similarity 59, member A
