The GANAB Polyclonal Antibody (CAB13851) is a valuable tool for researchers studying the GANAB protein, a key enzyme involved in protein folding and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications.The GANAB protein plays a crucial role in maintaining protein homeostasis and proper cell function, making it a target of interest in studies related to protein folding diseases such as neurodegenerative disorders and metabolic syndromes.
By targeting the GANAB protein, researchers can gain insights into the mechanisms underlying protein quality control and potentially develop therapeutic interventions for diseases characterized by protein misfolding.Overall, the GANAB Polyclonal Antibody offers researchers a reliable tool for the detection and analysis of GANAB protein levels in various cell types, facilitating further investigations into the role of this enzyme in protein folding pathways and its potential implications for disease development and treatment.
Product Name:
GANAB Rabbit Polyclonal Antibody
SKU:
CAB13851
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GANAB (NP_001265123.1).
This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease.
Purification Method:
Affinity purification
Gene ID:
23193
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GANAB Rabbit pAb (CAB13851) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
