Gamt Antibody (PACO26917)
- SKU:
- PACO26917
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Gamt Antibody (PACO26917)
The GAMT Polyclonal Antibody (PAC026917) is a crucial tool for researchers studying the GAMT gene, which encodes for the enzyme guanidinoacetate N-methyltransferase. This enzyme plays a key role in the biosynthesis of creatine, a vital molecule for energy metabolism in the muscles and brain.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the GAMT protein, researchers can accurately detect and analyze its expression in a variety of cell types. This makes the antibody well-suited for investigations in the fields of metabolism, neurobiology, and muscle physiology.
The GAMT enzyme deficiency is associated with disorders affecting creatine metabolism, leading to intellectual disability, seizures, and muscle weakness. Therefore, understanding the regulation and function of GAMT is essential for developing targeted therapies for these conditions. The PAC026917 antibody provides a valuable tool for researchers seeking to unravel the complexities of creatine metabolism and its impact on human health.
| Antibody Name: | Gamt Antibody (PACO26917) |
| Antibody SKU: | PACO26917 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Guanidinoacetate N-methyltransferase protein (1-236AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Gamt antibody at 2µg/ml + Rat liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 27 kDa Observed band size: 27 kDa . |
| Synonyms: | Guanidinoacetate N-methyltransferase (EC 2.1.1.2), Gamt |
| UniProt Protein Function: | Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development. |
| UniProt Protein Details: | |
| NCBI Summary: | catalyzes the last step of creatine biosynthesis [RGD, Feb 2006] |
| UniProt Code: | P10868 |
| NCBI GenInfo Identifier: | 120938 |
| NCBI Gene ID: | 25257 |
| NCBI Accession: | P10868.2 |
| UniProt Secondary Accession: | P10868 |
| UniProt Related Accession: | P10868 |
| Molecular Weight: | 26,407 Da |
| NCBI Full Name: | Guanidinoacetate N-methyltransferase |
| NCBI Synonym Full Names: | guanidinoacetate N-methyltransferase |
| NCBI Official Symbol: | Gamt  |
| NCBI Official Synonym Symbols: | GMTÂ Â |
| NCBI Protein Information: | guanidinoacetate N-methyltransferase |
| UniProt Protein Name: | Guanidinoacetate N-methyltransferase |
| UniProt Synonym Protein Names: | |
| Protein Family: | Guanidinoacetate N-methyltransferase |
| UniProt Gene Name: | Gamt  |
| UniProt Entry Name: | GAMT_RAT |
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