GALR2 Rabbit Polyclonal Antibody (CAB17577)
- SKU:
- CAB17577
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GALR2 Rabbit Polyclonal Antibody |
SKU: | CAB17577 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GALR2 (NP_003848.1). |
Sequence: | LLRG GQAV STTN LFIL NLGV ADLC FILC CVPF QATI YTLD GWVF GSLL CKAV HFLI FLTM HASS FTLA AVSL DRYL AIRY PLHS RELR TPRN ALAA IGLI W |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GAL2-R; GALNR2; GALR-2; GALR2 |
Positive Sample: | Mouse brain,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | cilium, plasma membrane |
Calculated MW: | 42kDa |
Observed MW: | 47kDa |
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
Purification Method: | Affinity purification |
Gene ID: | 8811 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |