GALR1 Antibody (PACO55514)
- SKU:
- PACO55514
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GALR1 Antibody (PACO55514)
The GALR1 Polyclonal Antibody (PACO55514) is a valuable tool for researchers studying GALR1, a G protein-coupled receptor that plays a key role in the regulation of various physiological processes, including hormone secretion, neuronal signaling, and pain modulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By specifically binding to the GALR1 protein, this antibody enables the detection and analysis of GALR1 expression in different cell types, making it an ideal choice for studies in neuroscience, endocrinology, and pain research.
Understanding the function and regulation of GALR1 is essential for uncovering its potential role in diseases such as neurodegenerative disorders, metabolic syndromes, and chronic pain conditions.Overall, the GALR1 Polyclonal Antibody offers researchers a reliable tool for investigating the physiological and pathological roles of GALR1 in various biological contexts, contributing to the development of novel therapeutic strategies targeting this important receptor.
| Antibody Name: | GALR1 Antibody (PACO55514) |
| Antibody SKU: | PACO55514 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Galanin receptor type 1 protein (293-349AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: HepG2 whole cell lysate. All lanes: GALR1 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39 kDa. Observed band size: 39 kDa. |
| Background: | Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Synonyms: | Galanin receptor type 1 (GAL1-R) (GALR-1), GALR1, GALNR GALNR1 |
| UniProt Protein Function: | GALR1: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 18q23 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:galanin receptor activity; peptide hormone binding; protein binding Biological Process: digestion; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of cortisol secretion; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P47211 |
| NCBI GenInfo Identifier: | 311033447 |
| NCBI Gene ID: | 2587 |
| NCBI Accession: | P47211.3 |
| UniProt Secondary Accession: | P47211,Q4VBL7, |
| UniProt Related Accession: | P47211 |
| Molecular Weight: | 38,953 Da |
| NCBI Full Name: | Galanin receptor type 1 |
| NCBI Synonym Full Names: | galanin receptor 1 |
| NCBI Official Symbol: | GALR1Â Â |
| NCBI Official Synonym Symbols: | GALNR; GALNR1Â Â |
| NCBI Protein Information: | galanin receptor type 1 |
| UniProt Protein Name: | Galanin receptor type 1 |
| Protein Family: | Galanin receptor |
| UniProt Gene Name: | GALR1Â Â |
| UniProt Entry Name: | GALR1_HUMAN |
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