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GALR1 Antibody (PACO03793)

SKU:
PACO03793
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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GALR1 Antibody (PACO03793)

The GALR1 Polyclonal Antibody (PACO03793) is a valuable tool for researchers studying GALR1, a galanin receptor involved in various physiological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been specifically validated for use in immunohistochemistry applications. By binding to the GALR1 protein, this antibody enables precise detection and analysis in different tissues and cell types, making it ideal for research in neuroscience, endocrinology, and metabolic disorders.

GALR1, a G-protein coupled receptor for the neuropeptide galanin, is known for its roles in regulating neurotransmission, pain perception, and energy metabolism. Its involvement in these pathways makes it a promising target for investigations into neurological disorders, chronic pain conditions, and metabolic diseases. Insights into GALR1 function could lead to the development of novel therapeutic strategies aimed at modulating these physiological processes for improved health outcomes.

Antibody Name:GALR1 Antibody
Antibody SKU:PACO03793
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human GALR1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GALR1; GALNR; GALNR1; Galanin receptor type 1; GAL1-R; GALR-1
UniProt Protein Function:GALR1: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:galanin receptor activity; peptide hormone binding; protein binding

Biological Process: digestion; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of cortisol secretion; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
UniProt Code:P47211
NCBI GenInfo Identifier:311033447
NCBI Gene ID:2587
NCBI Accession:P47211.3
UniProt Secondary Accession:P47211,Q4VBL7,
UniProt Related Accession:P47211
Molecular Weight:38,953 Da
NCBI Full Name:Galanin receptor type 1
NCBI Synonym Full Names:galanin receptor 1
NCBI Official Symbol:GALR1  
NCBI Official Synonym Symbols:GALNR; GALNR1  
NCBI Protein Information:galanin receptor type 1
UniProt Protein Name:Galanin receptor type 1
Protein Family:Galanin receptor
UniProt Gene Name:GALR1  
UniProt Entry Name:GALR1_HUMAN

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