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GALNT17 Antibody (PACO36746)

SKU:
PACO36746
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • GALNT17 Antibody PACO36746
  • GALNT17 Antibody PACO36746
€339

Description

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GALNT17 Antibody (PACO36746)

The Galnt17 Polyclonal Antibody (PAC036746) is a valuable tool for researchers studying Galnt17, a glycosyltransferase enzyme involved in protein glycosylation. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting Galnt17 in human samples, making it ideal for use in Western blot applications. By binding to the Galnt17 protein, this antibody enables accurate detection and analysis in various cell types, facilitating research in glycosylation pathways and related disease mechanisms.Galnt17 is known for its role in protein glycosylation, a post-translational modification essential for protein function and cellular processes.

Dysregulation of Galnt17 has been implicated in various diseases, including cancer and metabolic disorders, highlighting its importance as a molecular target for therapeutic interventions. By studying the function of Galnt17, researchers can gain insights into the roles of glycosylation in disease progression and potentially identify novel therapeutic strategies targeting this glycosyltransferase enzyme.

Antibody Name:GALNT17 Antibody (PACO36746)
Antibody SKU:PACO36746
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 17 protein (101-300AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human brain tissue using PACO36746 at dilution of 1:100.
Product ImageImmunohistochemistry of paraffin-embedded human heart tissue using PACO36746 at dilution of 1:100.
Background:May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Synonyms:Polypeptide N-acetylgalactosaminyltransferase 17 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 3) (GalNAc-T-like protein 3) (pp-GaNTase-like protein 3) (Protein-UDP acetylgalactosaminyltransferase-like protein 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3) (Williams-Beuren syndrome chromosomal region 17 protein), GALNT17, WBSCR17
UniProt Protein Function:WBSCR17: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. WBSCR17 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
UniProt Protein Details:

Protein type:EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: Golgi membrane; integral to membrane

Molecular Function:polypeptide N-acetylgalactosaminyltransferase activity; metal ion binding; carbohydrate binding

Biological Process: protein amino acid glycosylation

NCBI Summary:This gene encodes an N-acetylgalactosaminyltransferase. This gene is located centromeric to the common deleted region in Williams-Beuren syndrome (WBS), a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. This protein may play a role in membrane trafficking. [provided by RefSeq, Jan 2013]
UniProt Code:Q6IS24
NCBI GenInfo Identifier:51315852
NCBI Gene ID:64409
NCBI Accession:Q6IS24.2
UniProt Secondary Accession:Q6IS24,Q8NFV9, Q9NTA8,
UniProt Related Accession:Q6IS24
Molecular Weight:598
NCBI Full Name:Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3
NCBI Synonym Full Names:Williams-Beuren syndrome chromosome region 17
NCBI Official Symbol:WBSCR17  
NCBI Official Synonym Symbols:GALNT16; GALNT20; GALNTL3; GALNACT17; GalNAc-T5L  
NCBI Protein Information:putative polypeptide N-acetylgalactosaminyltransferase-like protein 3; galNAc-T-like protein 3; pp-GalNAc-transferase 20; pp-GaNTase-like protein 3; polypeptide GalNAc transferase 3; polypeptide GalNAc transferase-like protein 3; polypeptide N-acetylgalactosaminyltransferase-like 3; polypeptide N-acetylgalactosaminyltransferase WBSCR17; williams-Beuren syndrome chromosomal region 17 protein; protein-UDP acetylgalactosaminyltransferase-like protein 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
UniProt Protein Name:Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3
UniProt Synonym Protein Names:Polypeptide GalNAc transferase-like protein 3; GalNAc-T-like protein 3; pp-GaNTase-like protein 3; Protein-UDP acetylgalactosaminyltransferase-like protein 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3; Williams-Beuren syndrome chromosomal region 17 protein
Protein Family:Putative polypeptide N-acetylgalactosaminyltransferase-like protein
UniProt Gene Name:WBSCR17  
UniProt Entry Name:GLTL3_HUMAN
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