The GALNT16 Polyclonal Antibody (PACO39642) is a valuable tool for researchers studying GALNT16, an enzyme involved in the process of O-linked glycosylation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GALNT16 protein, this antibody enables the detection and analysis of GALNT16 in a variety of cell types, making it well-suited for investigations in the fields of glycobiology and cancer research.GALNT16 plays a crucial role in the glycosylation of proteins, a post-translational modification that impacts various cellular processes including cell signaling, adhesion, and immunity.
Dysregulation of glycosylation, including alterations in GALNT16 expression, has been linked to conditions such as cancer, diabetes, and neurodegenerative diseases. Research focused on understanding the function and regulation of GALNT16 is essential for developing targeted therapies and diagnostic tools for these complex disorders.
Antibody Name:
GALNT16 Antibody (PACO39642)
Antibody SKU:
PACO39642
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 16 protein (301-558AA)
Western blot. All lanes: GALNT16 antibody at 12µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 64, 61 kDa. Observed band size: 64, 49 kDa.
Background:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
Synonyms:
Polypeptide N-acetylgalactosaminyltransferase 16 (EC 2.4.1.41) (Polypeptide GalNAc transferase 16) (GalNAc-T16) (Polypeptide GalNAc transferase-like protein 1) (GalNAc-T-like protein 1) (pp-GaNTase-like protein 1) (Polypeptide N-acetylgalactosaminyltransferase-like protein 1) (Protein-UDP acetylgalactosaminyltransferase-like protein 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1), GALNT16, GALNTL1 KIAA1130
UniProt Protein Function:
GALNT16: an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Two alternatively spliced human isoforms have been described.Protein type: Membrane protein, integral; Transferase; EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesisChromosomal Location of Human Ortholog: 14q24.1Cellular Component: Golgi membrane; integral to membraneMolecular Function: polypeptide N-acetylgalactosaminyltransferase activity; metal ion binding; carbohydrate bindingBiological Process: protein amino acid glycosylation
Polypeptide GalNAc transferase 16; GalNAc-T16; Polypeptide GalNAc transferase-like protein 1; GalNAc-T-like protein 1; pp-GaNTase-like protein 1; Polypeptide N-acetylgalactosaminyltransferase-like protein 1; Protein-UDP acetylgalactosaminyltransferase-like protein 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1
