The GALNT14 Polyclonal Antibody (PAC038446) is a vital tool for researchers studying key proteins involved in post-translational modifications. GALNT14, also known as polypeptide N-acetylgalactosaminyltransferase 14, plays a crucial role in glycosylation processes within the cell.This polyclonal antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an excellent choice for Western blot applications. It specifically targets the GALNT14 protein, allowing for accurate detection and analysis in a variety of cell types.GALNT14 is involved in various cellular functions, including the modification of proteins through glycosylation, which can impact cellular interactions and signaling pathways.
Research into GALNT14 is essential for understanding its role in diseases such as cancer, where aberrant glycosylation patterns have been implicated in tumor progression and metastasis.By utilizing the GALNT14 Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying protein glycosylation and its implications for disease pathology, paving the way for potential therapeutic interventions targeting GALNT14 in cancer and other disorders.
Western blot. All lanes: GALNT14 antibody at 2µg/ml. Lane 1: Rat gonad tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 65, 61, 62 kDa. Observed band size: 65 kDa.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO38446 at dilution of 1:100.
Background:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
GALNT14: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.4.1.41; Transferase; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integralChromosomal Location of Human Ortholog: 2p23.1Cellular Component: Golgi membraneMolecular Function: polypeptide N-acetylgalactosaminyltransferase activityBiological Process: O-glycan processing
UniProt Protein Details:
NCBI Summary:
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]
