GALNT12 Antibody (PACO37782)
- SKU:
- PACO37782
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GALNT12 Antibody (PACO37782)
The GALNT12 Antibody (PAC037782) is a valuable tool for researchers studying GALNT12, an enzyme involved in protein glycosylation processes. This polyclonal antibody, raised in rabbits, is highly specific and reactive with human samples, providing reliable results in Western blot applications. By targeting the GALNT12 protein, this antibody allows for the detection and analysis of glycosylation patterns in different cell types, making it essential for studies in glycobiology and cancer research.
GALNT12 plays a crucial role in the attachment of sugars to proteins, influencing their stability, localization, and function. Aberrant glycosylation patterns have been linked to various diseases, including cancer, making GALNT12 a potential target for therapeutic intervention. Understanding the function of GALNT12 and its impact on cellular processes is key to developing novel treatments for glycosylation-related disorders.
| Antibody Name: | GALNT12 Antibody (PACO37782) |
| Antibody SKU: | PACO37782 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO37782 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO37782 at dilution of 1:100. |
| Background: | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. |
| Synonyms: | Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12), GALNT12 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011] |
| UniProt Code: | Q8IXK2 |
| NCBI GenInfo Identifier: | 15530299 |
| NCBI Gene ID: | 79695 |
| NCBI Accession: | AAH13945.1 |
| UniProt Secondary Accession: | Q8IXK2,Q5TCF7, Q8NG54, Q96CT9, Q9H771 |
| UniProt Related Accession: | Q8IXK2 |
| Molecular Weight: | 31,726 Da |
| NCBI Full Name: | GALNT12 protein |
| NCBI Synonym Full Names: | polypeptide N-acetylgalactosaminyltransferase 12 |
| NCBI Official Symbol: | GALNT12Â Â |
| NCBI Official Synonym Symbols: | CRCS1; GalNAc-T12Â Â |
| NCBI Protein Information: | polypeptide N-acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12); colorectal cancer, susceptibility to 1; polype |
| UniProt Protein Name: | |
| UniProt Synonym Protein Names: | |
| Protein Family: | Polypeptide N-acetylgalactosaminyltransferase |
| UniProt Gene Name: | |
| UniProt Entry Name: |
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