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GALNT12 Antibody (PACO37782)

SKU:
PACO37782
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • GALNT12 Antibody PACO37782
  • GALNT12 Antibody PACO37782
€359

Description

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GALNT12 Antibody (PACO37782)

The GALNT12 Antibody (PAC037782) is a valuable tool for researchers studying GALNT12, an enzyme involved in protein glycosylation processes. This polyclonal antibody, raised in rabbits, is highly specific and reactive with human samples, providing reliable results in Western blot applications. By targeting the GALNT12 protein, this antibody allows for the detection and analysis of glycosylation patterns in different cell types, making it essential for studies in glycobiology and cancer research.

GALNT12 plays a crucial role in the attachment of sugars to proteins, influencing their stability, localization, and function. Aberrant glycosylation patterns have been linked to various diseases, including cancer, making GALNT12 a potential target for therapeutic intervention. Understanding the function of GALNT12 and its impact on cellular processes is key to developing novel treatments for glycosylation-related disorders.

Antibody Name:GALNT12 Antibody (PACO37782)
Antibody SKU:PACO37782
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human gastric cancer using PACO37782 at dilution of 1:100.
Product ImageImmunohistochemistry of paraffin-embedded human small intestine tissue using PACO37782 at dilution of 1:100.
Background:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Synonyms:Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12), GALNT12
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]
UniProt Code:Q8IXK2
NCBI GenInfo Identifier:15530299
NCBI Gene ID:79695
NCBI Accession:AAH13945.1
UniProt Secondary Accession:Q8IXK2,Q5TCF7, Q8NG54, Q96CT9, Q9H771
UniProt Related Accession:Q8IXK2
Molecular Weight:31,726 Da
NCBI Full Name:GALNT12 protein
NCBI Synonym Full Names:polypeptide N-acetylgalactosaminyltransferase 12
NCBI Official Symbol:GALNT12  
NCBI Official Synonym Symbols:CRCS1; GalNAc-T12  
NCBI Protein Information:polypeptide N-acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12); colorectal cancer, susceptibility to 1; polype
UniProt Protein Name:
UniProt Synonym Protein Names:
Protein Family:Polypeptide N-acetylgalactosaminyltransferase
UniProt Gene Name:
UniProt Entry Name:
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