GALE Rabbit Polyclonal Antibody (CAB6595)
- SKU:
- CAB6595
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | GALE Rabbit Polyclonal Antibody |
SKU: | CAB6595 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE (NP_001121093.1). |
Sequence: | FSSS ATVY GNPQ YLPL DEAH PTGG CTNP YGKS KFFI EEMI RDLC QADK TWNA VLLR YFNP TGAH ASGC IGED PQGI PNNL MPYV SQVA IGRR EALN VFGN DYDT EDGT GVRD YIHV VDLA KGHI AALR KLKE QCGC RIYN LGTG TGYS VLQM VQAM EKAS GKKI PYKV VARR EGDV AACY ANPS LAQE ELGW TAAL GLDR MCED LWRW QKQN PSGF GTQA |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | SDR1E1; GALE |
Positive Sample: | SW480,SKOV3,HepG2,U-251MG,HeLa,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol |
Calculated MW: | 38kDa |
Observed MW: | 38kDa |
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and cognitive disability, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
Purification Method: | Affinity purification |
Gene ID: | 2582 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |