The Gale Polyclonal Antibody (CAB6595) is a valuable tool for researchers studying the Gale protein, a key player in immune regulation. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in a variety of research applications. The Gale protein has been implicated in immune regulation, specifically in inhibiting immune responses. By binding to the Gale protein, this antibody enables researchers to detect and analyze Gale in various cell types, providing crucial insights for studies in immunology and cancer research.In addition to its role in immune regulation, Gale has also been connected to modulating inflammation and allergic reactions, highlighting its potential importance in a variety of diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By understanding the activity of Gale, researchers can develop targeted therapies that harness or modulate immune function in these disease contexts.Overall, the Gale Polyclonal Antibody (CAB6595) is a valuable tool for researchers looking to study the role of Gale in immune regulation and disease processes, offering high reactivity and reliability in Western blot applications.
Product Name:
GALE Rabbit Polyclonal Antibody
SKU:
CAB6595
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE (NP_001121093.1).
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and cognitive disability, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
Purification Method:
Affinity purification
Gene ID:
2582
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GALE antibody (CAB6595) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
