The GALC Polyclonal Antibody (CAB3873) is a valuable tool for researchers studying GALC, a crucial enzyme involved in lipid metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications such as Western blotting. By binding specifically to the GALC protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a versatile tool for research in biochemistry and neurology.GALC, also known as galactocerebrosidase, is responsible for breaking down specific fats in the body, particularly within the nervous system.
Mutations in the GALC gene have been linked to disorders such as Krabbe disease, a rare and often fatal neurological condition. By studying the function and regulation of GALC, researchers aim to better understand these diseases and potentially develop new treatments or therapies.Overall, the GALC Polyclonal Antibody (CAB3873) offers a reliable and effective solution for scientists investigating lipid metabolism and related disorders. Its specificity and sensitivity make it an essential tool for advancing our knowledge of GALC and its role in maintaining cellular health.
Product Name:
GALC Rabbit Polyclonal Antibody
SKU:
CAB3873
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GALC (NP_000144.2).
This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
2581
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GALC Rabbit pAb (CAB3873) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
