The Galactosidase Alpha Rabbit Monoclonal Antibody (CAB5119) is a valuable tool for researchers studying galactosidase alpha, an enzyme involved in the hydrolysis of galactosides. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in various research applications including Western blotting.Galactosidase alpha plays a crucial role in carbohydrate metabolism, specifically in the breakdown of certain sugars like lactose. Dysregulation of this enzyme has been implicated in various diseases, making it a target of interest for researchers in fields such as biochemistry, genetics, and medicine.
By detecting and analyzing the expression of galactosidase alpha in different cell types, this antibody enables researchers to further investigate the function and regulation of this enzyme in normal physiological processes and disease states. Its high specificity and sensitivity make it a reliable tool for studies aimed at understanding the role of galactosidase alpha in health and disease.
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.
Purification Method:
Affinity purification
Gene ID:
2717
Clone Number:
ARC1213
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Galactosidase alpha (GLA) (GLA) Rabbit mAb (CAB5119) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
