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GAK Antibody (PACO21683)

SKU:
PACO21683
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$503

Description

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GAK Antibody (PACO21683)

The GAK Polyclonal Antibody (PACO21683) from Assay Genie is a valuable tool for researchers studying the protein GAK, which plays a crucial role in cellular processes such as endocytosis and intracellular trafficking. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.GAK, also known as cyclin-G-associated kinase, is involved in the regulation of clathrin-mediated endocytosis and is important for proper cell division and growth. Dysfunction of GAK has been linked to various diseases, making it a promising target for pharmaceutical research in areas such as cancer and neurodegenerative disorders.

By using the GAK Polyclonal Antibody, researchers can detect and analyze GAK protein levels in different cell types, providing valuable insights into its role in cellular pathways and disease mechanisms. This antibody is a valuable tool for advancing our understanding of GAK function and developing targeted therapies for diseases associated with GAK dysregulation.

Antibody Name:GAK Antibody (PACO21683)
Antibody SKU:PACO21683
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:200
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from Internal of human GAK.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from 293 cells, using GAK antibody.
Background:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. The MGC Project Team; Genome Res. 14:2121-2127(2004).
Synonyms:Cyclin G-associated kinase; EC 2.7.11.1; kinase GAK;
UniProt Protein Function:GAK: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; NAK familyChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; membrane; vesicleMolecular Function: protein bindingBiological Process: Golgi organization and biogenesis
UniProt Protein Details:
NCBI Summary:In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Code:O14976
NCBI GenInfo Identifier:17375734
NCBI Gene ID:2580
NCBI Accession:O14976.2
UniProt Secondary Accession:O14976,Q5U4P5, Q9BVY6
UniProt Related Accession:O14976
Molecular Weight:134,464 Da
NCBI Full Name:Cyclin-G-associated kinase
NCBI Synonym Full Names:cyclin G associated kinase
NCBI Official Symbol:GAK  
NCBI Official Synonym Symbols:DNAJ26; DNAJC26  
NCBI Protein Information:cyclin-G-associated kinase
UniProt Protein Name:Cyclin-G-associated kinase
UniProt Synonym Protein Names:
Protein Family:Cyclin-G-associated kinase
UniProt Gene Name:GAK  
UniProt Entry Name:GAK_HUMAN
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