The GAK Polyclonal Antibody (PACO09395) is a powerful tool for researchers studying the protein GAK, which plays a crucial role in various cellular processes including cell cycle progression and mitotic spindle assembly. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot experiments. By targeting the GAK protein, this antibody enables researchers to detect and analyze GAK expression in different cell types, making it an ideal choice for studies in molecular biology and cancer research.
GAK, also known as cyclin G-associated kinase, is involved in multiple cellular pathways such as clathrin-mediated endocytosis and autophagy, making it a key player in maintaining cellular homeostasis. Its role in regulating cell division and intracellular trafficking makes it a potential therapeutic target for diseases like cancer and neurodegenerative disorders. Research into the function of GAK is essential for developing novel treatments that target these pathways and improve patient outcomes.
cyclin G associated kinase;GAK;FLJ16629;FLJ40395;MGC99654 ;
UniProt Protein Function:
GAK: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; NAK familyChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; membrane; vesicleMolecular Function: protein bindingBiological Process: Golgi organization and biogenesis
UniProt Protein Details:
NCBI Summary:
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
