GAK Antibody (PACO09395)
- SKU:
- PACO09395
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GAK Antibody (PACO09395) |
Antibody SKU: | PACO09395 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human GAK |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | cyclin G associated kinase;GAK;FLJ16629;FLJ40395;MGC99654 ; |
UniProt Protein Function: | GAK: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; NAK familyChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; membrane; vesicleMolecular Function: protein bindingBiological Process: Golgi organization and biogenesis |
UniProt Protein Details: | |
NCBI Summary: | In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
UniProt Code: | O14976 |
NCBI GenInfo Identifier: | 17375734 |
NCBI Gene ID: | 2580 |
NCBI Accession: | O14976.2 |
UniProt Secondary Accession: | O14976,Q5U4P5, Q9BVY6 |
UniProt Related Accession: | O14976 |
Molecular Weight: | 134,464 Da |
NCBI Full Name: | Cyclin-G-associated kinase |
NCBI Synonym Full Names: | cyclin G associated kinase |
NCBI Official Symbol: | GAKÂ Â |
NCBI Official Synonym Symbols: | DNAJ26; DNAJC26Â Â |
NCBI Protein Information: | cyclin-G-associated kinase |
UniProt Protein Name: | Cyclin-G-associated kinase |
UniProt Synonym Protein Names: | |
Protein Family: | Cyclin-G-associated kinase |
UniProt Gene Name: | GAKÂ Â |
UniProt Entry Name: | GAK_HUMAN |