The GAGE5 Polyclonal Antibody (PAC026901) is a valuable tool for researchers studying the GAGE5 protein, a member of the GAGE family of proteins known for their involvement in cancer development and progression. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the GAGE5 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in cancer biology and therapeutic development.
The GAGE5 protein, a tumor antigen expressed in various cancer types, has been implicated in promoting tumorigenesis and metastasis. Its role in cancer pathogenesis makes it a compelling target for research aimed at understanding the molecular mechanisms driving cancer progression and identifying potential therapeutic targets. Investigating the function of GAGE5 with the help of this antibody is crucial for advancing our knowledge of cancer biology and developing innovative treatment strategies for cancer patients.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO26901 at dilution of 1:100.
Synonyms:
G antigen 5 (GAGE-5) (Cancer/testis antigen 4.5) (CT4.5), GAGE5
UniProt Protein Function:
GAGE5: a member of a family of the GAGE family of proteins that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xp11.4-p11.2Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]
