The Gag-Pol Antibody (PACO33588) is a high-quality antibody designed for use in research involving the Gag-Pol protein, an essential component of retroviruses such as HIV. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the Gag-Pol protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable tool for studying retroviral replication and potential therapeutic targets.
The Gag-Pol protein is crucial for the replication and assembly of retroviruses, making it a key target for antiviral drug development and understanding viral pathogenesis. This antibody can aid in the investigation of the mechanisms underlying retroviral replication, as well as the development of novel strategies to combat retroviral infections. Its high specificity and reliability make it a valuable asset for researchers in virology, infectious diseases, and antiviral drug discovery.
Antibody Name:
gag-pol Antibody (PACO33588)
Antibody SKU:
PACO33588
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human immunodeficiency virus type 1 group M subtype B
Immunogen:
Recombinant Human immunodeficiency virus type 1 group M subtype B Gag-Pol polyprotein protein (1-440AA)
Gag-Pol polyprotein: Mediates, with Gag polyrotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shutt off translation.Matrix protein p17: Targets the polyprotein to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus (). Matrix protein is part of the pre-integration complex. Implicated in the release from host cell mediated by Vpu. Binds to RNA ().
Pr160Gag-PolCleaved into the following 11 chains:Matrix protein p17; MA; Capsid protein p24; CA; Spacer peptide p2; Nucleocapsid protein p7; NC; Transframe peptide; TF; p6-pol; p6*; Protease (EC:3.4.23.16)Alternative name(s):PR; Retropepsin
