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GADD45GIP1 Antibody (PACO05673)

SKU:
PACO05673
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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GADD45GIP1 Antibody (PACO05673)

The GADD45GIP1 Polyclonal Antibody (PACO05673) is a crucial tool for researchers studying GADD45GIP1, a protein involved in cell growth, apoptosis, and DNA damage response pathways. This antibody, generated in rabbits, shows strong reactivity with human samples and has been validated for Western blot applications. By specifically binding to the GADD45GIP1 protein, this antibody allows for the detection and analysis of GADD45GIP1 in a variety of cell types, making it an excellent choice for studies in molecular biology and cancer research.

GADD45GIP1, also known as Growth Arrest and DNA Damage-Inducible Protein 45 Gamma Interacting Protein 1, plays a critical role in cellular processes linked to tumor suppression and DNA repair. Its involvement in regulating cell proliferation and apoptosis makes it a promising target for research on cancer development and progression. Understanding the function of GADD45GIP1 can provide valuable insights into the mechanisms underlying cancer and may lead to the development of new therapeutic strategies targeting this protein.

Antibody Name:GADD45GIP1 Antibody (PACO05673)
Antibody SKU:PACO05673
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:Human
Immunogen:Synthesized peptide derived from the Internal region of human CRIF1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GADD45GIP1; PLINP1; PRG6; Growth arrest and DNA damage-inducible proteins-interacting protein 1; CKII β-associating protein; CR6-interacting factor 1; CRIF1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive
UniProt Protein Function:GADD45GIP1: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Down-regulated by p53/TP53 in apoptotic cells. Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.Protein type: Nuclear receptor co-regulator; Cell cycle regulationChromosomal Location of Human Ortholog: 19p13.2Cellular Component: mitochondrion; mitochondrial matrix; nucleusMolecular Function: protein bindingBiological Process: viral reproduction; mitochondrial translation; organelle organization and biogenesis; cell cycle
UniProt Protein Details:
NCBI Summary:This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
UniProt Code:Q8TAE8
NCBI GenInfo Identifier:74730346
NCBI Gene ID:90480
NCBI Accession:Q8TAE8.1
UniProt Secondary Accession:Q8TAE8,Q8IVM3, Q8TE51, Q969P9, Q9BSM6
UniProt Related Accession:Q8TAE8
Molecular Weight:25kDa
NCBI Full Name:Growth arrest and DNA damage-inducible proteins-interacting protein 1
NCBI Synonym Full Names:growth arrest and DNA-damage-inducible, gamma interacting protein 1
NCBI Official Symbol:GADD45GIP1  
NCBI Official Synonym Symbols:PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2  
NCBI Protein Information:growth arrest and DNA damage-inducible proteins-interacting protein 1; CR6 interacting factor 1; CKII beta binding protein 2; CKII beta-associating protein; p53-responsive gene 6 protein; 39S ribosomal protein L59, mitochondrial; papillomavirus L2 interacting nuclear protein 1; growth arrest- and DNA damage-inducible GADD45G-interacting protein
UniProt Protein Name:Growth arrest and DNA damage-inducible proteins-interacting protein 1
UniProt Synonym Protein Names:39S ribosomal protein L59, mitochondrial; MRP-L59; CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive gene 6 protein
Protein Family:Growth arrest and DNA damage-inducible protein
UniProt Gene Name:GADD45GIP1  
UniProt Entry Name:G45IP_HUMAN

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