The GADD45G Polyclonal Antibody (CAB10286) is specifically designed for research involving GADD45G, a key protein involved in cellular stress response and DNA repair processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications, enabling detection and analysis of GADD45G protein expression in various cell types.GADD45G, part of the growth arrest and DNA damage-inducible gene family, plays a crucial role in maintaining genomic stability and regulating cell cycle progression in response to environmental stressors. Its involvement in DNA repair mechanisms and cell growth control makes it a promising target for research in fields such as cancer biology, genotoxicity, and environmental toxicology.
By utilizing the GADD45G Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of GADD45G in cellular stress responses, DNA damage repair pathways, and its potential implications in disease processes. This antibody serves as a powerful tool for studies aiming to understand the molecular mechanisms underlying cell survival and DNA integrity maintenance, with implications for therapeutic strategies targeting GADD45G-associated pathways.
Product Name:
GADD45G Rabbit Polyclonal Antibody
SKU:
CAB10286
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-159 of human GADD45G (NP_006696.1).
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.
Purification Method:
Affinity purification
Gene ID:
10912
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from RAW264.7 cells, using GADD45G Rabbit pAb (CAB10286) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5min.
