The GADA Antibody (PAC033992) is a valuable tool for researchers studying autoimmune diseases, specifically type 1 diabetes. This polyclonal antibody is raised in rabbits and exhibits high reactivity with human samples. Validated for use in various applications including Western blot, the GADA Antibody binds specifically to the glutamic acid decarboxylase 65 (GAD65) protein, enabling precise detection and analysis in different cell types.GAD65 is an enzyme involved in the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA) and is a major autoantigen in type 1 diabetes. The presence of GAD65 autoantibodies, such as GADA, is associated with the destruction of insulin-producing beta cells in the pancreas.
Research on GADA and its target protein is crucial for understanding the pathogenesis of type 1 diabetes and developing novel therapeutic strategies.By using the GADA Antibody in their studies, researchers can gain insights into the role of GAD65 autoantibodies in autoimmune destruction, leading to advancements in the diagnosis, treatment, and management of type 1 diabetes. The antibody's specificity and sensitivity make it an essential tool for investigating the mechanisms underlying autoimmune diseases.
Antibody Name:
gadA Antibody (PACO33992)
Antibody SKU:
PACO33992
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Glutamate decarboxylase α protein (1-466AA)
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acid, c conditions. The ability to survive transit through the acid, c conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
Synonyms:
Glutamate decarboxylase α (GAD-alpha) (EC 4.1.1.15), gadA, gadS
UniProt Protein Function:
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
UniProt Protein Details:
NCBI Summary:
RpoS regulon. [More information is available at EcoGene: EG50009]. GadA, a glutamate decarboxylase enzyme, is part of the glutamate-dependent acid resistance system 2 (AR2) which confers resistance to extreme acid conditions. [More information is available at EcoCyc: EG50009].
