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Gad2 Antibody (PACO26885)

SKU:
PACO26885
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
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Description

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Gad2 Antibody (PACO26885)

The GAD2 Antibody (PACO26885) is a specialized tool for researchers studying the protein GAD2, known for its involvement in neurotransmission and neurological disorders. This polyclonal antibody, generated in rabbits, has high specificity for detecting GAD2 in human samples and has been validated for use in Western blotting applications. By targeting the GAD2 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in neuroscience and neurology.GAD2, also called glutamate decarboxylase 2, is a key enzyme involved in the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA).

Dysregulation of GAD2 expression and activity has been implicated in neurological conditions such as epilepsy, anxiety disorders, and Parkinson's disease. The ability to study GAD2 levels and localization in tissues and cell cultures is crucial for understanding its role in neurophysiology and pathophysiology, ultimately paving the way for the development of novel therapeutic interventions targeting GAD2-related disorders.

Antibody Name:Gad2 Antibody (PACO26885)
Antibody SKU:PACO26885
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Glutamate decarboxylase 2 protein (1-585AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Catalyzes the production of GABA.
Synonyms:Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid, decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform), Gad2, Gad65
UniProt Protein Function:GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family.
UniProt Protein Details:

Protein type:Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; Lyase; Other Amino Acids Metabolism - taurine and hypotaurine; EC 4.1.1.15

Cellular Component: axon; cell junction; cytoplasm; cytoplasmic vesicle; cytosol; Golgi apparatus; membrane; perinuclear region of cytoplasm; plasma membrane; synapse; synaptic vesicle membrane

Molecular Function:carboxy-lyase activity; catalytic activity; glutamate binding; glutamate decarboxylase activity; lyase activity; protein heterodimerization activity; pyridoxal phosphate binding

Biological Process: carboxylic acid metabolic process; glutamate decarboxylation to succinate; neurotransmitter biosynthetic process

UniProt Code:P48320
NCBI GenInfo Identifier:124517709
NCBI Gene ID:14417
NCBI Accession:NP_032104.2
UniProt Secondary Accession:P48320,O35519,
Molecular Weight:69.2 kDa
NCBI Full Name:glutamate decarboxylase 2
NCBI Synonym Full Names:glutamic acid decarboxylase 2
NCBI Official Symbol:Gad2  
NCBI Official Synonym Symbols:GAD65; Gad-2; GAD(65); 6330404F12Rik  
UniProt Protein Name:Glutamate decarboxylase 2
UniProt Synonym Protein Names:65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform
Protein Family:Glutamate decarboxylase
UniProt Gene Name:Gad2  
UniProt Entry Name:DCE2_MOUSE

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