GAD67/GAD1 Rabbit Polyclonal Antibody (CAB2938)
- SKU:
- CAB2938
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Frequently bought together:
Description
Product Name: | GAD67/GAD1 Rabbit Polyclonal Antibody |
SKU: | CAB2938 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 432-594 of human GAD67/GAD1 (NP_000808.2). |
Sequence: | AGYL FQPD KQYD VSYD TGDK AIQC GRHV DIFK FWLM WKAK GTVG FENQ INKC LELA EYLY AKIK NREE FEMV FNGE PEHT NVCF WYIP QSLR GVPD SPQR REKL HKVA PKIK ALMM ESGT TMVG YQPQ GDKA NFFR MVIS NPAA TQSD IDFL IEEI ERLG QDL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | GAD; SCP; CPSQ1; DEE89; GAD67/GAD1 |
Positive Sample: | 293T,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | axon terminus, cell cortex, cytoplasm, GABA-ergic synapse, inhibitory synapse, plasma membrane, presynaptic active zone |
Calculated MW: | 67kDa |
Observed MW: | 67kDa |
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Purification Method: | Affinity purification |
Gene ID: | 2571 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |