The GAD1 Polyclonal Antibody (CAB2938) is a valuable tool for researchers studying GAD1, an important enzyme involved in the production of the neurotransmitter gamma-aminobutyric acid (GABA). This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the GAD1 protein, this antibody enables accurate detection and analysis of GAD1 in various cell types, making it ideal for studies in neuroscience, psychiatry, and neurology.GAD1 plays a crucial role in the regulation of GABA levels in the brain, making it a key player in neurotransmission and neuronal excitability.
Dysregulation of GAD1 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and anxiety disorders. Understanding the function of GAD1 is essential for gaining insights into these conditions and developing targeted therapeutics.By utilizing the GAD1 Polyclonal Antibody (CAB2938), researchers can advance their understanding of GAD1 function and its role in neurological health and disease. This antibody provides a reliable tool for investigating the intricate mechanisms underlying GAD1 activity, paving the way for new discoveries in the field of neuroscience.
Product Name:
GAD67/GAD1 Rabbit Polyclonal Antibody
SKU:
CAB2938
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 432-594 of human GAD67/GAD1 (NP_000808.2).
axon terminus, cell cortex, cytoplasm, GABA-ergic synapse, inhibitory synapse, plasma membrane, presynaptic active zone
Calculated MW:
67kDa
Observed MW:
67kDa
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Purification Method:
Affinity purification
Gene ID:
2571
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using (CAB2938) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
