The GABRR2 Polyclonal Antibody (CAB10111) is a valuable tool for researchers studying the GABRR2 protein, a subunit of the GABA(A) receptor involved in inhibitory neurotransmission. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot and immunohistochemistry applications. By binding to the GABRR2 protein, this antibody allows for the detection and analysis of GABA(A) receptor subunit expression in various cell types and tissues.The GABRR2 protein is essential for the function of GABA(A) receptors, which play a crucial role in regulating neuronal activity and maintaining the balance between excitation and inhibition in the brain. Dysfunction of GABA(A) receptors has been implicated in a variety of neurological disorders, including epilepsy, anxiety, and schizophrenia.
By studying the expression and activity of GABRR2, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets for drug development.Overall, the GABRR2 Polyclonal Antibody is a powerful tool for investigating the role of GABA(A) receptors in neurobiology and advancing our understanding of the molecular mechanisms underlying neurological disorders. Its high specificity and reactivity with human samples make it a valuable asset for researchers seeking to unravel the complexities of synaptic transmission and brain function.
Product Name:
GABRR2 Rabbit Polyclonal Antibody
SKU:
CAB10111
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human GABRR2 (NP_002034.3).
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability.
Purification Method:
Affinity purification
Gene ID:
2570
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GABRR2 antibody (CAB10111) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
