The GABRR1 Polyclonal Antibody (CAB5745) is a valuable tool for researchers studying GABRR1, a subunit of the GABA-A receptor that plays a key role in synaptic inhibition in the brain. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot assays. By binding to the GABRR1 protein, this antibody enables the detection and analysis of GABRR1 expression in various cell types, making it an ideal choice for studies in neuroscience and neurology.GABRR1 is essential for the proper functioning of the GABAergic neurotransmission system, which is involved in regulating neuronal excitability and synaptic transmission.
Dysregulation of GABA-A receptor subunits, including GABRR1, has been implicated in various neurological disorders such as epilepsy, anxiety, and sleep disorders. Understanding the role of GABRR1 in these conditions is crucial for the development of targeted therapies that modulate GABAergic signaling.Overall, the GABRR1 Polyclonal Antibody is a reliable tool for researchers looking to investigate the role of GABRR1 in normal brain function and neurological disorders. Its specificity and sensitivity make it a valuable asset for advancing our understanding of GABAergic neurotransmission and its implications for brain health and disease.
Product Name:
GABRR1 Rabbit Polyclonal Antibody
SKU:
CAB5745
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 365-465 of human GABRR1 (NP_002033.2).
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2569
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GABRR1 antibody (CAB5745) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
