The GABRG2 Polyclonal Antibody (CAB1733) is a crucial tool for researchers studying the GABA receptor subunit gamma-2 (GABRG2), a key player in the inhibitory neurotransmission process in the brain. This antibody, generated in rabbits, demonstrates high specificity and sensitivity towards human samples, making it ideal for Western blot experiments.GABRG2 is essential for maintaining the balance between excitatory and inhibitory neurotransmission, and dysregulation of this receptor subunit has been linked to various neurological disorders such as epilepsy, anxiety, and schizophrenia. By utilizing the GABRG2 Polyclonal Antibody, researchers can effectively detect and analyze the expression of GABRG2 in different cell types, contributing to the advancement of neuroscience research.
Moreover, understanding the role of GABRG2 in neuronal signaling and synaptic function is crucial for developing novel therapeutic interventions for neurological conditions associated with aberrant GABAergic neurotransmission. The GABRG2 Polyclonal Antibody serves as a valuable tool for investigating the function and regulation of GABRG2, providing insights that could potentially lead to the development of targeted treatments for neurological disorders.
Product Name:
GABRG2 Rabbit Polyclonal Antibody
SKU:
CAB1733
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 400-500 of human GABRG2 (NP_944493.2).
Sequence:
VSNR KPSK DKDK KKKN PLLR MFSF KAPT IDIR PRSA TIQM NNAT HLQE RDEE YGYE CLDG KDCA SFFC CFED CRTG AWRH GRIH IRIA KMDS YARI FFPT A
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
2566
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GABRG2 antibody (CAB1733) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
