The GABRD Polyclonal Antibody (CAB16016) is specifically designed for research involving GABRD, a protein that plays a crucial role in regulating neuronal activity in the brain. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GABRD protein, this antibody enables easy detection and analysis in various cell types, making it an ideal tool for studies in neuroscience and neurology.GABRD is a key component of the GABA-A receptor, which is responsible for inhibiting neuronal activity in the brain. Dysregulation of GABRD has been implicated in various neurological disorders, including epilepsy, anxiety, and insomnia.
Understanding the role of GABRD in these conditions is essential for developing targeted therapies to modulate neuronal activity and treat these disorders effectively.Overall, the GABRD Polyclonal Antibody (CAB16016) is a valuable tool for researchers in the field of neuroscience who are studying GABRD and its role in neurological disorders. Its high reactivity and specificity make it a reliable option for Western blot analysis, providing valuable insights into the mechanisms underlying neuronal activity in the brain.
Product Name:
GABRD Rabbit Polyclonal Antibody
SKU:
CAB16016
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 31-248 of human GABRD (NP_000806.2)).
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
2563
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of MCF7, using GABRD Rabbit pAb (CAB16016) at 1:3500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
