The Gabra4 Polyclonal Antibody (CAB3870) is a vital tool for researchers studying the Gabra4 protein, a subunit of the GABAA receptor involved in neurotransmission and neuronal signaling. This antibody is specifically raised in rabbits and exhibits high reactivity with human samples, making it an excellent choice for use in Western blotting applications. By binding to the Gabra4 protein, this antibody enables the detection and analysis of Gabra4 in various cell types, facilitating research in neuroscience and pharmacology.The Gabra4 protein is a key player in the inhibitory neurotransmission mediated by the GABAA receptor, making it crucial for maintaining the balance of excitation and inhibition in the brain.
Dysregulation of Gabra4 has been implicated in neurological disorders such as epilepsy, anxiety, and insomnia. By studying the function and regulation of Gabra4, researchers can gain valuable insights into the pathophysiology of these conditions and potentially develop novel therapeutic interventions targeting the GABAA receptor.Overall, the Gabra4 Polyclonal Antibody is an essential tool for investigating the role of Gabra4 in neuronal function and dysfunction, paving the way for new discoveries in the field of neuroscience and neuropharmacology.
Product Name:
GABRA4 Rabbit Polyclonal Antibody
SKU:
CAB3870
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 36-258 of human GABRA4 (NP_000800.2).
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
Purification Method:
Affinity purification
Gene ID:
2557
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of rat kidney, using GABRA4 antibody (CAB3870) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
