The Gabra3 Polyclonal Antibody (PAC021542) offered by Assay Genie is a valuable tool for researchers studying the Gabra3 protein, which plays a key role in the function of GABA receptors in the brain. This antibody was developed using rabbits, ensuring high reactivity with human samples, and has been validated for use in Western blot applications.Gabra3 is known for its involvement in synaptic transmission and neuronal excitability, making it a crucial target for studies related to neurological disorders such as epilepsy and anxiety. The Gabra3 Polyclonal Antibody binds specifically to the Gabra3 protein, allowing for accurate detection and analysis in various cell types.
This makes it an ideal choice for researchers in the field of neuroscience who are interested in understanding the mechanisms underlying these conditions.By using the Gabra3 Polyclonal Antibody, researchers can gain insights into the role of Gabra3 in regulating neuronal activity and potentially uncover new therapeutic targets for treating neurological disorders. Its versatility and reliability make it a valuable tool for advancing our understanding of the brain and developing innovative treatments for related diseases.
Antibody Name:
Gabra3 Antibody (PACO21542)
Antibody SKU:
PACO21542
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:
Human, Rat, Mouse
Immunogen:
Peptide sequence around aa. 33~37(R-R-Q-E-P)derived from Rat GABA A Receptor a3.
Form:
Liquid
Storage Buffer:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates Kaupmann, K. et al. (1997) Nature 386, 239-46.
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extract from rat brain and mouse brain tissue and C6 cells using GABA A Receptor a3 Antibody.
GABRA3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channelProtein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channelCellular Component: postsynaptic membrane; integral to membrane; plasma membrane; synapse; cell junctionMolecular Function: chloride channel activity; protein binding; GABA-A receptor activity; extracellular ligand-gated ion channel activityBiological Process: synaptic transmission; chloride transport; gamma-aminobutyric acid signaling pathway
UniProt Protein Details:
NCBI Summary:
may mediate inhibitory GABA responses; may play a role in synaptic transmission in the visual cortex [RGD, Feb 2006]
