The Gabra3 Polyclonal Antibody (CAB11636) is a valuable tool for researchers studying the Gabra3 protein, a member of the GABA-A receptor family which plays a crucial role in neurotransmission and neuronal excitability. This antibody, produced in rabbits, is highly sensitive in detecting Gabra3 in human samples and has been validated for use in Western blot applications.Gabra3 is known for its involvement in mediating the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, making it a key player in the regulation of inhibitory neurotransmission. Dysregulation of Gabra3 has been linked to various neurological disorders, including epilepsy, anxiety disorders, and alcohol addiction.
With its high specificity and sensitivity, the Gabra3 Polyclonal Antibody is an essential tool for researchers studying the role of Gabra3 in neurological disorders and exploring potential therapeutic strategies targeting this protein. Its ability to reliably detect Gabra3 in different cell types and tissues makes it a valuable asset in advancing our understanding of the underlying mechanisms of neurological diseases and developing targeted treatments.
Product Name:
GABRA3 Rabbit Polyclonal Antibody
SKU:
CAB11636
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-276 of human GABRA3 (NP_000799.1).
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
Purification Method:
Affinity purification
Gene ID:
2556
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GABRA3 Rabbit pAb (CAB11636) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
