The GABRA2 Polyclonal Antibody (CAB1803) is an essential tool for researchers studying the GABRA2 receptor, a crucial component of the GABAergic system in the brain. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.The GABRA2 receptor is known to play a key role in mediating the effects of the neurotransmitter GABA, contributing to the regulation of neuronal excitability and neurotransmission. Dysregulation of GABRA2 has been implicated in various neurological disorders, including epilepsy, anxiety, and alcohol dependence.By targeting the GABRA2 receptor, researchers can gain insights into the mechanisms underlying these disorders and explore potential therapeutic strategies.
The GABRA2 Polyclonal Antibody enables the detection and analysis of GABRA2 protein expression in different cell types, making it a valuable tool for studies in neuroscience and drug discovery.Understanding the function and regulation of the GABRA2 receptor is essential for advancing our knowledge of neurological disorders and developing targeted therapies that could improve patient outcomes. The GABRA2 Polyclonal Antibody is a crucial resource for researchers dedicated to unraveling the complexities of the GABAergic system in health and disease.
Product Name:
GABRA2 Rabbit Polyclonal Antibody
SKU:
CAB1803
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2).
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2555
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GABRA2 Rabbit pAb (CAB1803) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3s.
