The Gabra2 Polyclonal Antibody (CAB14185) is a valuable tool for researchers studying the Gabra2 protein, a critical component of the GABA-A receptor complex in the brain. This antibody, generated in rabbits, exhibits high reactivity with human samples and is optimized for use in Western blot applications. By binding specifically to Gabra2, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it well-suited for investigations in neuroscience and pharmacology.Gabra2 is a key subunit of the GABA-A receptor, a major inhibitory neurotransmitter receptor in the central nervous system. Dysregulation of GABA-A receptor function, including alterations in Gabra2 expression, has been linked to various neurological disorders such as epilepsy, anxiety, and alcohol dependence.
Research on Gabra2 is essential for elucidating the mechanisms underlying these conditions and developing targeted therapies for their treatment.By utilizing the Gabra2 Polyclonal Antibody, researchers can further their understanding of GABA-A receptor function and its role in neurological health and disease. This antibody is a valuable resource for studies investigating the molecular and cellular mechanisms of Gabra2, with the potential to advance our knowledge of brain function and inform the development of novel therapeutic strategies.
Product Name:
GABRA2 Rabbit Polyclonal Antibody
SKU:
CAB14185
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2).
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2555
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GABRA2 antibody (CAB14185) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3s.
